Debromohymenialdisine ≥95% (by HPLC)

Synonyms: DBHA-SKFDBHSKF 108753

350-290-C100
89149-426EA 161.16 USD
89149-426
Debromohymenialdisine ≥95% (by HPLC)
Debromohymenialdisine

Chk inhibitor


Inhibitor of G2 DNA damage checkpoint (IC50=8µM) and check point kinases 1 (Chk1) (IC50=3µM) and 2 (Chk2) (IC50=3.5µM). Unlike other checkpoint inhibitors DBH does not inhibit ataxia-telangiectasia mutated (ATM) or ATM-Rad3-related protein. Also inhibits MAP kinase kinase 1 (MEK-1) (IC50=881nM) but is not as potent as 10Z-hymenialdisine (Prod. No. ALX-350-289) (IC50=6nM).


Isolated from sponge Axinella carteri.

Formula: C₁₁H₁₁N₅O₂
MW: 245.24 g/mol
CAS Number: 125118-55-0
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