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Lactacystin (native), Enzo Life Sciences

Supplier: Enzo Life Sciences

Proteasome inhibitor

Cell permeable and irreversible proteasome inhibitor. Specifically inhibits 26S proteasome (MCP; multicatalytic proteinase complex). Blocks proteasome activity by targeting the catalytic beta-subunit. Has no effect on serine or cysteine proteases. Induces apoptosis in human monoblast U937 cells. Also inhibits NF-kappaB activation by inhibiting IkappaB degradation. Inhibits the ubiquitin proteasome pathway in cell culture (IC50=10µM). Inhibits cathepsin A. Upregulates HSP70 and HSP22, suggesting an initial neuroprotective pathway.

Isolated from Streptomyces sp.

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Size Supplier No. VWR Catalog Number Unit Price Quantity
0.1 mg 350-245-MC01 89149-320 Each Retrieving Restricted
0.5 mg 350-245-MC05 89149-322 Each Retrieving Restricted
1 mg 350-245-M001 89149-318 Each Retrieving Restricted
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Purity ≥97% (HPLC)
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