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Supplier: Enzo Life Sciences
Synonyms: 1′-Epimer dihydrocarpanone

Cytoprotective and antioxidant

Diastereomeric lignan with cytoprotective and antioxidant activities in cultured hepatocytes. Inhibitor of LPS-inducible iNOS (NOS II), TNF-alpha and COX-2 expression in macrophages through suppression of IkappaBalpha phosphorylation and p65 nuclear translocation and of C/EBP and/or AP-1 activation, which may have constitutive anti-inflammatory effects. Suppressor of NF-kappaB by inhibiting transactivation activity of the RelA subunit. Inhibits staurosporine (Prod. No. ALX-380-014)-induced apoptosis. Inhibits RANKL-induced osteoclastogenesis by reducing ROS generation.

Isolated from Saururus chinensis.

Formula: C₂₀H₂₀O₆
MW: 356.4 g/mol
CAS Number: 177931-17-8



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Size Supplier No. VWR Catalog Number Unit Price Quantity
5 mg 350-116-M005 89149-098 Each Retrieving Restricted
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