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Rottlerin, Enzo Life Sciences

Supplier: Enzo Life Sciences
PKCdelta inhibitor

Mitochondrial uncoupler that depolarizes the mitochondrial membrane potential, reduces cellular ATP levels, activates 5‘-AMP-activated protein kinase (AMPK) and affects mitochondrial production of reactive oxygen species (ROS). Potent activator of multiple Ca2+-sensitive K+ channels. Blocks several kinases and non-kinase proteins in vitro. Has been widely-used as a selective inhibitor of protein kinase Cdelta (PKCdelta) (IC50=3-6µM). Although there is extensive published documentation to support the use of rottlerin as a selective PKCdelta inhibitor, there has been some controversy in the literature over this claim. Some of this controversy may arise from the fact that rottlerin is a promiscuous inhibitor and therefore may not always display the same properties as would be expected from a classical 1:1 inhibitor. However, there are studies indicate that rottlerin has no direct effect on PKCdelta and that it should not be used to determine the involvement of PKCdelta in biological processes. Induces autophagy by inhibition of mTORC1 signaling.

Isolated from Mallotus philippinensis.



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Size Supplier No. VWR Catalog Number Unit Price Quantity
10 mg 350-075-M010 89149-012 Each Retrieving Restricted
25 mg 350-075-M025 89149-014 Each Retrieving Restricted
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SPECIFICATIONS

Purity ≥98% (HPLC)
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