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Okadaic acid (high purity), Enzo Life Sciences

Supplier: Enzo Life Sciences
Inhibitor of PP1 and PP2A

Okadaic acid is a naturally occuring polyether toxin produced by marine dinoflagellates. It is a potent and selective inhibitor of proteion phosphatases, inhibiting PP2A completely at 1nM and PP1 at higher concentrations (IC50=10-15nM). PP2B is much less sensitive to okadaic acid than PP1, while PP2C is not inhibited. This selectivity is the basis for an improved identification and quantification procedure for these enzymes. The hydrophobic backbone of okadaic acid enables it to enter cells where it stimulates intracellular proteion phosphorylation. It mimics the effects of insulin, enhances transmitter release at neuromuscular junctions, causes vasodilation. Okadaic acid is an extremely useful tool for studying cellular processes that are regulated by phosphorylation. Does not affect activity of acid phosphatase, alkaline phosphatase and tyorsine phosphatase. Non-phorbol type tumor promoter. Induces apoptosis in human breast carcinoma cells (MB-231 and MCF-7) and in myeloid cells, but inhibits glucocorticoid-induced apoptosis in T cell hybridomas. Is a tumor promoter. Has shown contractile effects on smooth muscle and heart muscle. Significantly increases cyclin B1 expression in adult neurons.

Isolated from Prorocentrum concavum by preparative flash, medium pressure and high performance liquid chromatography.

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Size Supplier No. VWR Catalog Number Unit Price Quantity
100 µg 350-003-C100 89148-892 Each Retrieving Restricted
1 mg 350-003-M001 89148-894 Each Retrieving Restricted
25 µg 350-003-C025 89148-888 Each Retrieving Restricted
50 µg 350-003-C050 89148-890 Each Retrieving Restricted
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Purity ≥98% (HPLC)
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