ABT-888 ≥98% (by HPLC)

Supplier: Enzo Life Sciences

270-444-M005 270-444-M025 270-444-M001
89147-920EA 105.63 USD
89147-920 89147-922 76002-508
ABT-888 ≥98% (by HPLC)
ABT-888

PARP inhibitor


Potent inhibitor of PARP-1 and PARP-2 (potency ≤5nM in vitro). Does not inhibit other NAD-binding enzymes. Has minimal CYP450 inhibition and induction. Shows broad spectrum of chemo- and radiopotentiation. Is toxic to both oxic and hypoxic cells. Enantiomeric purity ≥97% suitable for in vivo studies. Does not show inherent cytotoxicity and shows no single agent activity in tumor models. Has excellent bioavailability and good blood-brain permeation. Increases tumor growth delay resulting from radiation and DNA-damaging agents.

CAS Number: 912445-05-7
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