Smoothened agonist ≥95%
Supplier: Enzo Life Sciences
Synonyms:
SAG
, 3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[3-(4-pyridinyl)benzyl]-1-benzothiophene-2-carboxamide
Smoothened ligand
A potent cell-permeable benzothiophene compound that modulates the coupling of Smo with its downstream effector by interacting with the Smo heptahelical domain (KD = 59 nM). Shown to induce Hedgehog pathway activation (EC50= ~3 nM in NIH 3T3-derived Shh-LIGHT2 cells) and counteracts Cyclopamine (BML-GR334) inhibition of Smo. Reported to act as an activator at low concentrations and as an inhibitor at very high concentrations.
Formula:
C₂₈H₂₈ClN₃OS MW: 490.062 g/mol |
MDL Number:
MFCD22581513 CAS Number: 912545-86-9 |
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