Ratjadone A (synthetic)

Supplier: Enzo Life Sciences

270-346-C002
89147-664EA 256.65 USD
89147-664
Ratjadone A (synthetic)
Ratjadone A

Represents a class of natural compounds, which inhibit proliferation in eukaryotes by blocking nuclear export. As potent as leptomycin B (Prod. No. ALX-380-100) and specific for G1/S checkpoint. Cytotoxic secondary metabolite (IC50=50pg/ml in mouse cell line L929) that arrests tumor cells in the G1 phase at remarkably low concentrations (50pg/ml in HeLa cell line KB3.1). Inhibits the binding between the nuclear export signal (NES) of proteins and the chromosome maintenance region protein (CRM1). Anticancer compound. Belongs to the family of orphan ligands which include polyketides like leptomycin B, callystatin A and other related compounds.

Formula: C₂₈H₄₀O₅
MW: 456.6 g/mol
CAS Number: 163564-92-9
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