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Y-27632 . dihydrochloride, Enzo Life Sciences

Supplier: Enzo Life Sciences
ROCK inhibitor

Highly potent, cell permeable, selective and ATP competitive inhibitor of ROCK1 and ROCK2 (IC50=800nM). Acts as a potent inhibitor of agonist-induced Ca2+ sensitization of myosin phosphorylation and smooth muscle contractions. Blocks cell spreading and suppresses RhoA-induced formation of stress fibers in hepatic stellate cells. Significantly reduces the increase of inflammatory cytokines after reperfusion, preventing the development of acute renal failure. Produces cardioprotective effects. Suppresses tumor cell invasion. Inhibits superoxide production, intrahepatic metastasis of human hepatocellular carcinoma as well as high K+-induced contractions in vascular smooth muscle. Mimics effects of β-agonists on human cells. Has antinociceptive effect.

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Size Supplier No. VWR Catalog Number Unit Price Quantity
1 mg 270-333-M001 89147-642 Each Retrieving Restricted
25 mg 270-333-M025 89147-646 Each Retrieving Restricted
5 mg 270-333-M005 89147-644 Each Retrieving Restricted
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To order chemicals, medical devices, or other restricted products please provide identification that includes your business name and shipping address via email or fax 484.881.5997 referencing your VWR account number . Acceptable forms of identification are:

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Purity ≥98% (HPLC)
Purity Detail Enantiomeric excess ≥96%
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