Y-27632 dihydrochloride ≥98% (by HPCE)

Supplier: Enzo Life Sciences

Synonyms: trans-4-((R)-1-Aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide dihydrochloride

270-333-M001 270-333-M005 270-333-M025
89147-644EA 314.2 USD
89147-644 89147-646 89147-642
Y-27632 dihydrochloride ≥98% (by HPCE)
Y-27632 dihydrochloride

ROCK inhibitor


Highly potent, cell permeable, selective and ATP competitive inhibitor of ROCK1 and ROCK2 (IC50=800nM). Acts as a potent inhibitor of agonist-induced Ca2+ sensitization of myosin phosphorylation and smooth muscle contractions. Blocks cell spreading and suppresses RhoA-induced formation of stress fibers in hepatic stellate cells. Significantly reduces the increase of inflammatory cytokines after reperfusion, preventing the development of acute renal failure. Produces cardioprotective effects. Suppresses tumor cell invasion. Inhibits superoxide production, intrahepatic metastasis of human hepatocellular carcinoma as well as high K+-induced contractions in vascular smooth muscle. Mimics effects of β-agonists on human cells. Has antinociceptive effect.

Formula: C₁₄H₂₁N₃O·2HCl
MW: 247.3·72.9 g/mol
MDL Number: MFCD03490488
CAS Number: 129830-38-2
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