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Anti-Glucocorticoid Receptor Beta Rabbit Polyclonal Antibody

Supplier: Enzo Life Sciences
Glucocorticoids are a family of steroids necessary for the regulation of energy metabolism, and the immune and inflammatory responses. These compounds exert their effect through their interaction with the glucocorticoid receptor (GR) and that complex's subsequent association with DNA. All normal mammalian tissues examined to date have been shown to contain GR.The human GR exists in two forms, α and β, which are thought to be the result of alternative splicing of a single gene. Sequence analysis indicates that the α and β forms of human GR are 777 and 742 amino acids long, respectively. They are identical up to residue 727, after which they diverge. After ligand binding, the 94kDa GRα isoform has been observed to translocate from the cytoplasm to the nucleus where it regulates gene expression. In contrast, the 90kDa GRβ isoform does not appear to bind either glucocorticoid agonists or antagonists, and has been localized predominantly in the nucleus independent of hormone treatment in some human cell lines. Studies suggest that human GRβ might function as a dominant negative inhibitor of GRα activity.

For Immunocytochemistry, Immunoprecipitation, Western Blot

Recognizes human GRbeta. Detects a band of ~90kDa by Western blot.

Type: Primary
Antigen: GLUCOCORTICOID RECEPTOR BETA
Clonality: Polyclonal
Clone:
Conjugation:
Epitope:
Host: Rabbit
Isotype:
Reactivity: Human



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Size Supplier No. VWR Catalog Number Unit Price Quantity
50 µL 210-154-R050 89145-248 Each Retrieving Restricted

Temperature sensitive This Item is temperature sensitive and has specific temperature and storage requirements for shipping/delivery. Requires a maximum 2 day delivery.

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SPECIFICATIONS

Antigen Symbol GCRB
Antigen Name Glucocorticoid Receptor Beta
Reactivity Human
Clonality Polyclonal
Antibody Type Primary
Host Rabbit
Western Blot Yes
ImmunoChemistry Yes
ImmunoPrecipitation Yes
Form Liquid. In PBS containing 0.05% sodium azide.
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