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Humanin (human), Enzo Life Sciences

Supplier: Enzo Life Sciences
Bax inhibitor

Humanin was originally identified as an anti-apoptotic peptide of 24 aa encoded in a cDNA that rescued neuronal cells from apoptosis induced by presenilin mutants associated with familial Alzheimer's disease and by amyloid-beta protein. Mutagenesis studies showed that the cysteine at position 8 of the humanin peptide is critical for its anti-apoptotic function. It has now been shown that Bax (Bcl-2 associated X protein), an apoptosis-inducing protein, interacts with humanin. Humanin prevents the translocation of Bax from the cytosol to mitochondria. Humanin peptides also block Bax association with isolated mitochondria, and suppress cytochrome c release in vitro.

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Size Supplier No. VWR Catalog Number Unit Price Quantity
0.5 mg 158-011-MC05 89143-470 Each Retrieving Restricted
1 mg 158-011-M001 89143-468 Each Retrieving Restricted
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Protein/Peptide Name Humanin
Purity ≥98% (HPLC)
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