TBTU (O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate)
Supplier: BACHEM AMERICAS INC
Synonyms:
TBTU
Sequence: N-[(1H-Benzotriazol-1-yl)(dimethylamino)-methylene]-N-methylmethanaminium tetrafluoroborate N-oxide
Synonym(s): O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium-tetrafluoroborate
TBTU is successfully used as coupling reagent in solid phase peptide synthesis. It acts as an excellent activating reagent causing low racemization during condensation of peptide segments. A study of the structure of TBTU in solid state as well as in solution by Abdelmoty et al. showed that the compound is a guanidinium N-oxide and not an uronium salt.
Formula:
C₁₁H₁₆BF₄N₅O MW: 321.1 g/mol Storage Temperature: Refrigerator |
MDL Number:
MFCD00077413 CAS Number: 125700-67-6 |
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