BACEN-1890

4047620.0005 4047620.0025
N-1890.0005BAEA 185.73 USD
N-1890.0005BA N-1890.0025BA
BACEN-1890
Sequence: 3,5-Difluorophenylacetyl-Ala-Phg-OMe
Synonym(s): DAPM

DAPM, a cell-permeable γ-secretase inhibitor with anti-aggregation properties that dose-dependently inhibits amyloid β-protein (Aβ) secretion in 7PA2 Chinese hamster ovary (CHO) cells with an half-maximal inhibitory concentration of IC₅₀ ~ 10 nM. DAPM prevents oligomer formation by selectively blocking the Aβ dimer and trimer formation at doses that allow appreciable monomer production.
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