Pyr-Arg-Thr-Lys-Arg-AMC Trifluoroacetate

Supplier: Bachem

4018149.0025 4018149.0005
I-1650.0025BAEA 515.11 USD
I-1650.0025BA I-1650.0005BA
Pyr-Arg-Thr-Lys-Arg-AMC Trifluoroacetate
Proteins and Peptides
The fluorogenic substrate pERTKR-AMC is efficiently cleaved by furin, a mammalian homolog of the yeast Kex2 endoprotease (kcat/Km approx. 2·10⁴ M-¹s-¹). As a calcium-dependent serine protease associated with Golgi membranes, furin is responsible for the secretory processing of precursor proteins at paired basic residues. Also cleaved by proprotein convertase 4. IpERTKR-AMC is an excellent substrate for flavivirin.
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