Pyr-Arg-Thr-Lys-Arg-AMC TrifluoroacetateSupplier: Bachem
I-1650.0025BAEA 515.11 USDI-1650.0025BA I-1650.0005BA
Proteins and Peptides
The fluorogenic substrate pERTKR-AMC is efficiently cleaved by furin, a mammalian homolog of the yeast Kex2 endoprotease (kcat/Km approx. 2·10⁴ M-¹s-¹). As a calcium-dependent serine protease associated with Golgi membranes, furin is responsible for the secretory processing of precursor proteins at paired basic residues. Also cleaved by proprotein convertase 4. IpERTKR-AMC is an excellent substrate for flavivirin.