I-1120.0050 I-1120.0250
I-1120.0050BAEA 367.04 USD InStock
I-1120.0050BA I-1120.0250BA
Proteins and Peptides
Sequence: Boc-Val-Pro-Arg-AMC
CAS-No.: 65147-04-8
Mol.weight: 627.74
SumFormula: C₃₁H₄₅N₇O₇
Bulk item no.: I-1120
EINECS no.: -
MDL no.: MFCD00058181

Thrombin substrates are often cleaved as well by trypsin and trypsin-like enzymes, e.g. I-1365, I-1560, J-1120, and L-1150.

Boc-VPR-AMC, a specific, highly fluorogenic substrate for thrombin and the thrombin-staphylocoagulase complex. The thrombin assay has been used for the indirect determination of coagulation factor III. Trypsin, tryptase from rat mast cells, and two trypsin-like enzymes from sperm of the ascidian Halocynthia roretzi, acrosin and spermosin, also hydrolyze this substrate. Furthermore, Boc-VPR-AMC is cleaved by the Kex2 endoprotease (kexin, previously known as proteinase yscF), a membrane-bound, calcium-dependent serine protease from yeast α-cells.
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