BACED-2240

4027174.0005 4027174.0001
D-2240.0005BAEA 854.39 USD
D-2240.0005BA D-2240.0001BA
BACED-2240
Sequence: DL-2,3-Isopropylideneglycerylmethyl resin (200-400 mesh)

This glycerine-derived "polymeric ketal" can be turned into a polymeric 1,2-diol by acid-catalyzed aqueous cleavage or transketalation with ethylene glycol (C.C.Leznoff and J.Y.Wong). Both polymer derivatives can be reacted with carbonyl compounds. So Fmoc-amino aldehydes and acetals (e.g. Fmoc-NHCH₂CH(OCH₃)₂) bound to this resin yield, after routine Fmoc/tBu SPPS and acid-catalyzed cleavage, useful peptide derivatives, e.g. for ligation. Hirose et al. obtained the chitinase inhibitor argadin containing an Asp β-aldehyde residue via Fmoc-SPPS employing acetalization to the liberated resin-bound glycerine.
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