Diphenyldiazomethane resin, polymer-supported 200-400 meshSupplier: BACHEM AMERICAS INC
Diphenyldiazomethane was used industrially for producing benzhydryl esters (diphenylmethyl esters) of β-lactam antibiotics. This "polymeric diphenyldiazomethane" readily reacts with carboxylic acids, e.g. Fmoc-amino acids, which need not to be activated. Products can be cleaved from this very acid-sensitive resin derivative with 1-5 % TFA in dichloromethane.
- Substitution: 0.7-1.3 mmol/g