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Fmoc-Cys(SASRIN™ resin)-OH (200-400 mesh)

Supplier: BACHEM AMERICAS INC

D-2170.0001 D-2170.0005
Sequence: Fmoc-Cys(SASRIN™ resin)-OH (200-400 mesh)
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Bulk item no.: D-2170
Synonym(s):
EINECS no.:
MDL no.: MFCD00801579
Substitution: 0.3-0.6 mmol/g

This resin has been developed to allow C-terminal modification of cysteine-containing peptides. Fmoc-protected cysteine is linked to SASRIN™-resin by its thiol moiety, which thus is already protected. After derivatization of the carboxylic acid (and, if desired, standard Fmoc-SPPS) lthe modified cysteine derivative can be cleaved with TFA/water/triisopropylsilane (94:4:2, v/v/v) from the SASRIN™-resin. Extending the peptide chain at the C-terminus can be achieved by activation of the side-chain linked cysteine carboxylic acid and coupling to additional amino acids. Cys linked to a resin by its thiol function was oxidized with MCPBA after esterification and Nα-modification (Yamada et al.). DBU-induced elimination yielded dehydroalanine derivatives.




 

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Size Supplier No. VWR Catalog Number Unit Price Quantity
1 g D-2170.0001 D-2170.0001BA Each (1g) Retrieving

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

5 g D-2170.0005 D-2170.0005BA Each (5g) Retrieving

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

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SPECIFICATIONS

Storage Temperature +5 ± 3 °C
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