These peptides correspond to the C-terminus of the 65-residue polypeptide hirudin, a potent thrombin inhibitor found in the saliva of the leech Hirudo medicinalis. Treatment of hirudin with carboxypeptidase Y has shown that the last 5 amino acids are essential for its inhibitory activity.
Synthetic peptide. Lepirudin is an anticoagulant which functions as a direct thrombin inhibitor. Offered under Bolar Exemption: All APIs that are sold for development of drug products still patent protected are offered under Bolar Exemption only. The following disclaimer applies: These products are offered and sold in small quantities only and solely for uses reasonably related to privileged trials and studies for obtaining marketing authorization required by law (Bolar Exemption). Bachem cannot be made liable for any infringement of intellectual property rights. It is the sole and only responsibility of the purchaser or user of these products to comply with the relevant national rules and regulations.
