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Amyloid beta/A4 Protein Precursor₇₇₀ (740-770) Trifluoroacetate

Supplier: Bachem

4048249.0001

H-6216.0001BAEA 473.19 USD

H-6216.0001BA

Amyloid beta/A4 Protein Precursor₇₇₀ (740-770) Trifluoroacetate

Proteins and Peptides

See also the product family 'Secretase Inhibitors and Substrates'.comprising products related to β- and γ-secretase.

Amyloid β/A4 Protein Precursor₇₇₀ (740-770) corresponds to a C-terminal amyloid precursor protein (APP) fragment known as C31. This fragment is intracellularly generated by proteolytic cleavage of APP by caspases-8 and -9. C31 had a proapoptotic and a cytotoxic effect on neuronal cells and was shown to be present in brains of Alzheimer's disease (AD) patients. In cultured cells caspase cleavage of APP was induced by amyloid β-protein and the subsequent generation of C31 contributed to the apoptotic cell death associated with amyloid β-protein. Amyloid precursor binding protein BP1 (APP-BP1) a cell cycle protein which is increased in AD brain was demonstrated to bind to the C31 region of APP and to mediate APP-induced apoptosis.

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