IFN-γ Antagonist


4030819.1000 4030819.0500
H-2722.1000BAEA 775.84 USD
H-2722.1000BA H-2722.0500BA
IFN-γ Antagonist
Proteins and Peptides
Sequence: H-Ala-Tyr-Cys(Acm)-Arg-Asp-Gly-Lys-Ile-Gly-Pro-Pro-Lys-Leu-Asp-Ile-Arg-Lys-Glu-Glu-Lys-Gln-Ile-OH
CAS-No.: 158040-83-6
Mol.weight: 2629.08
SumFormula: C₁₁₅H₁₉₄N₃₄O₃₄S
Bulk item no.: H-2722
Synonym(s): (Tyr¹²¹,Cys(Acm)¹²²)-IFN-γ Receptor (120-141) (human)
EINECS no.: -
MDL no.: MFCD00677173

Lymphokines are soluble proteins that act as local hormones. They possess powerful immunoregulatory properties.

This peptide derived from the ligand binding site of the human γ-interferon (IFN-γ) receptor is an antagonist of human IFN-γ. It inhibited human IFN-γ-induced expression of HLR/DR antigen on Colo 205 cells with an approximate IC₅₀ of 35 µM. Immobilized peptide specifically bound recombinant human IFN-γ (H-1728). Tyrosine substitution at residue 121 allowed facile quantification and conjugation of the peptide.
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