H-Ser-Ile-Lys-Val-Ala-Val-OH

H-2684.0005 H-2684.0001
H-2684.0005BAEA 782.2 USD
H-2684.0005BA H-2684.0001BA
H-Ser-Ile-Lys-Val-Ala-Val-OH
The hexapeptide SIKVAV corresponds to residues 2099-2104 of the laminin α1 chain. SIKVAV has been shown to modulate tumor invasion, metastasis and angiogenesis. It also induced the synthesis of prostaglandin E₂, interstitial collagenase, and gelatinase B in monocyte cell cultures. Laminin fragments containing the SIKVAV sequence may contribute to the inflammatory response at sites of wound healing. They may also play a role in the excessive induction of metalloproteinases in chronic inflammatory lesions.
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