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Galanin (1-13)-Pro-Pro-(Ala-Leu-)₂Ala amide

Sequence: H-Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Pro-Pro-Ala-Leu-Ala-Leu-Ala-NH₂
CAS-No.: 143896-17-7
Mol.weight: 1981.33
SumFormula: C₉₄H₁₄₅N₂₃O₂₄
Bulk item no.: H-2576
Synonym(s): M40
EINECS no.: -
MDL no.: MFCD00671424

M40, a peptide containing the N-terminal galanin sequence (1-13), is an antagonist of the galanin receptor. M40 significantly antagonized galanin-induced feeding behavior at doses approximately equimolar to the active doses of rat galanin. M40 inhibited the binding of (¹²⁵I-Tyr²⁶)-galanin (porcine) in rat hypothalamic membranes with an IC₅₀ value of 15 nM. Coadministration of M40 with a muscarinic M1 agonist may enhance the efficacy of cholinergic treatments for the cognitive deficits of Alzheimer disease.

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Size Supplier No. VWR Catalog Number Unit Price Quantity
0.5 mg H-2576.0500 H-2576.0500BA Each (1mg) Retrieving Restricted
1 mg H-2576.1000 H-2576.1000BA Each (1mg) Retrieving Restricted
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Protein/Peptide Name Galanin (1-13)-Pro-Pro-(Ala-Leu-)₂Ala amide
Synonyms M40
CAS No. 143896-17-7
Molecular Weight 1981.33
Molecular Formula C₉₄H₁₄₅N₂₃O₂₄
Storage Conditions -20 ± 5 °C
Peptide Galanin (1-13)-Pro-Pro-(Ala-Leu-)₂Ala amide
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