Galanin (1-13)-Pro-Pro-(Ala-Leu-)₂Ala amide

Supplier: Bachem
4030654.0500 4030654.1000
H-2576.0500BAEA 275.57 USD
H-2576.0500BA H-2576.1000BA
Galanin (1-13)-Pro-Pro-(Ala-Leu-)₂Ala amide
Proteins and Peptides
M40, a peptide containing the N-terminal galanin sequence (1-13), is an antagonist of the galanin receptor. M40 significantly antagonized galanin-induced feeding behavior at doses approximately equimolar to the active doses of rat galanin. M40 inhibited the binding of (¹²⁵I-Tyr²⁶)-galanin (porcine) in rat hypothalamic membranes with an IC₅₀ value of 15 nM. Coadministration of M40 with a muscarinic M1 agonist may enhance the efficacy of cholinergic treatments for the cognitive deficits of Alzheimer disease.
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