Cyclo(-Arg-Gly-Asp-D-Phe-Val) TrifluoroacetateSupplier: Bachem
H-2574.0005BAEA 515.11 USDH-2574.0005BA H-2574.0001BA
Proteins and Peptides
c(RGDfV) is a potent inhibitor of cell adhesion. It inhibited tumor cell adhesion to laminin and vitronectin substrates. In vivo investigations in rats provided the first evidence of its utility in the amelioration of ischemic acute renal failure. c(RGDfV) inhibited tubular obstruction by preventing cell-cell adhesion. Hammes et al. showed that the cyclopeptide can also be used to prevent retinal neovascularization. c(RGDfV) binds to αvβ3 receptors.