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Fibronectin Fragment (1377-1388)

Sequence: H-His-Ser-Arg-Asn-Ser-Ile-Thr-Leu-Thr-Asn-Leu-Thr-OH
CAS-No.: 162257-99-0
Mol.weight: 1356.50
SumFormula: C₅₆H₉₇N₁₉O₂₀
Bulk item no.: H-2572
EINECS no.: -
MDL no.: MFCD00675386

Fibronectin fragment H-2572 inhibited fibronectin binding to the platelet membrane glycoprotein (GP) IIb/IIIa by interacting directly with this receptor, with an IC₅₀ of about 104 µM. HSRNSITLTNLT also inhibited the binding of fibrinogen to GPIIb/IIIa, as well as platelet aggregation. This indicates that this peptide derived from the cell binding domain of fibronectin comprises an RGD-independent GPIIb/IIIa binding site localized within the residues His¹³⁷⁷ and Ile¹³⁸².

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Size Supplier No. VWR Catalog Number Unit Price Quantity
1 mg H-2572.0001 H-2572.0001BA Each (1mg) Retrieving Restricted
5 mg H-2572.0005 H-2572.0005BA Each (5mg) Retrieving Restricted
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Protein/Peptide Name Fibronectin fragment (1377-1388)
CAS No. 162257-99-0
Molecular Weight 1356.50
Molecular Formula C₅₆H₉₇N₁₉O₂₀
Storage Temperature -20 ± 5 °C
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