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Thrombin Receptor Antagonist

H-2514.1000 H-2514.0500
Sequence: H-Met-Ser-Arg-Pro-Ala-Cys-Pro-Asn-Asp-Lys-Tyr-Glu-OH
CAS-No.: 207553-92-2
Mol.weight: 1410.60
SumFormula: C₅₈H₉₁N₁₇O₂₀S₂
Bulk item no.: H-2514
Synonym(s): T1
EINECS no.: -
MDL no.: MFCD00467126

PAR peptides (TRAP peptides and thrombin receptor-like peptides) activate the proteinase-activated receptors PAR-1 to PAR-4.

The peptide T1, MSRPACPNDKYE, is based on the sequence of the thrombin receptor domain that functions as a tethered ligand for the receptor itself. T1 has been selected from a phage peptide library as an inhibitor of thrombin triggered platelet aggregation, serotonin release and tyrosine phosphorylation. Its anti-aggregatory activity was about ten-fold higher than that of the previously reported peptide antagonists of the thrombin receptor. MSRPACPNDKYE has served as model peptide in protein modification and MS studies.



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Size Supplier No. VWR Catalog Number Unit Price Quantity
0.5 mg H-2514.0500 H-2514.0500BA Each (1mg) Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

1 mg H-2514.1000 H-2514.1000BA Each (1mg) Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

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Protein/Peptide Name Thrombin Receptor Antagonist
Protein Synonyms T1, MSRPACPNDKYE
CAS No. 207553-92-2
Molecular Weight 1410.60
Molecular Formula C₅₈H₉₁N₁₇O₂₀S₂
Storage Conditions -20 ± 5 °C
Salt Trifluoroacetate
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