Thrombin Receptor Antagonist Trifluoroacetate

Supplier: Bachem
4031303.0500 4031303.1000
H-2514.1000BAEA 275.57 USD
H-2514.1000BA H-2514.0500BA
Thrombin Receptor Antagonist Trifluoroacetate
PAR peptides (TRAP peptides and thrombin receptor-like peptides) activate the proteinase-activated receptors PAR-1 to PAR-4.

The peptide T1, MSRPACPNDKYE, is based on the sequence of the thrombin receptor domain that functions as a tethered ligand for the receptor itself. T1 has been selected from a phage peptide library as an inhibitor of thrombin triggered platelet aggregation, serotonin release and tyrosine phosphorylation. Its anti-aggregatory activity was about ten-fold higher than that of the previously reported peptide antagonists of the thrombin receptor. MSRPACPNDKYE has served as model peptide in protein modification and MS studies.
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