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H-2508.0500 H-2508.1000
Sequence: Cyclo(-Gly-Asn-Trp-His-Gly-Thr-Ala-Pro-Asp)-Trp-Phe-Phe-Asn-Tyr-Tyr-Trp-OH
CAS-No.: 151308-34-8
Mol.weight: 2043.19
SumFormula: C₁₀₃H₁₁₅N₂₃O₂₃
Bulk item no.: H-2508
Synonym(s): RES-701-1
EINECS no.: -
MDL no.: MFCD00924333

Endothelins are peptides with exceptional vasoconstrictor potency. They play an important role in intercellular communications.

The cyclic peptide RES-701-1, originally isolated from the culture broth of Streptomyces sp. RE-701, shows high selectivity for ET-B receptors. RES-701-1 inhibited ET-1 binding to ET-B receptors with an IC₅₀ value of 10 nM and blocked ET-B receptor-mediated responses. It may provide a powerful tool for understanding the physiological roles of the ET-B receptor.



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Size Supplier No. VWR Catalog Number Unit Price Quantity
0.5 mg H-2508.0500 H-2508.0500BA Each (1mg) Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

1 mg H-2508.1000 H-2508.1000BA Each (1mg) Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

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Protein/Peptide Name Cyclo(-Gly-Asn-Trp-His-Gly-Thr-Ala-Pro-Asp)-Trp-Phe-Phe-Asn-Tyr-Tyr-Trp-OH
Protein Synonyms RES-701-1
CAS No. 151308-34-8
Molecular Weight 2043.19
Molecular Formula C₁₀₃H₁₁₅N₂₃O₂₃
Storage Conditions -20 ± 5 °C
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