BQ-788

Supplier: Bachem
4026108.0005 4026108.0001
H-2492.0005BAEA 1585 USD
H-2492.0005BA H-2492.0001BA
BQ-788
Proteins and Peptides
Endothelins are peptides with exceptional vasoconstrictor potency. They play an important role in intercellular communications.

In vitro, BQ-788 potently and competitively inhibited ¹²⁵I-labeled ET-1 binding to ET-B receptors on human Girardi heart cells (IC₅₀= 1.2 nM). However, BQ-788 only poorly inhibited ET-1 binding to ET-A receptors on human neuroblastoma cell line SK-N-MC cells (IC₅₀= 1300 nM). Thus the ET-B receptor antagonist BQ788 may be considered as a powerful tool for investigating the role of ET in physiological and pathological processes.
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