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Sequence: Pyr-Glu-Pro-NH₂
CAS-No.: 85541-78-2
Mol.weight: 354.36
SumFormula: C₁₅H₂₂N₄O₆
Bulk item no.: H-2464
Synonym(s): FPP#Fertilization-Promoting Peptide#pE-E-P-NH2
EINECS no.: -
MDL no.: MFCD00076815

Fertilization-promoting peptide (FPP), a TRH analog, was previously purified and characterized from both rabbit prostate and human semen. Nanomolar concentrations of this peptide have been shown to enhance capacitation of mouse epididymal spermatozoa with a concomitant increase in fertilizing ability. It was also detected in the thyroid gland. According to a study of Nguyen et al. Pyr-Glu-Pro-NH₂ opposes the cholinergic effect of TRH in the mammalian CNS: Co-perfusion with an equivalent of TRH in the rat hippocampus resulted in a significant attenuation of TRH-induced acetylcholine release.

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Size Supplier No. VWR Catalog Number Unit Price Quantity
250 mg H-2464.0250 H-2464.0250BA Each (250mg) Retrieving Restricted
50 mg H-2464.0050 H-2464.0050BA Each (50mg) Retrieving Restricted
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Protein/Peptide Name (Glu²)-TRH
Synonyms FPP, Fertilization-Promoting Peptide
CAS No. 85541-78-2
Molecular Weight 354.36
Molecular Formula C₁₅H₂₂N₄O₆
Storage Conditions -20 ± 5 °C
Peptide (Glu²)-TRH
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