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Stichodactyla helianthus Neurotoxin (ShK)

Supplier: BACHEM AMERICAS INC
Sequence: H-Arg-Ser-Cys-Ile-Asp-Thr-Ile-Pro-Lys-Ser-Arg-Cys-Thr-Ala-Phe-Gln-Cys-Lys-His-Ser-Met-Lys-Tyr-Arg-Leu-Ser-Phe-Cys-Arg-Lys-Thr-Cys-Gly-Thr-Cys-OH
CAS-No.: 172450-46-3
Mol.weight: 4054.83
SumFormula: C₁₆₉H₂₇₄N₅₄O₄₈S₇
Bulk item no.: H-2358
Synonym(s): ShK
EINECS no.: -
MDL no.:

These monosubstituted analogs of ShK toxin, a class of K channel blocking peptide toxins derived from the sea anemone Stichodactyla helianthus, were prepared in order to identify functionally important residues. Hereby it has been shown that the location of Lys²² within a helical structure represents a unique difference between the interactive surfaces of the sea anemone and scorpion toxins.

ShK-toxin, originally isolated from the sea anemone Stichodactyla helianthus, has been found to inhibit the specific binding of dendrotoxin I to rat brain membranes. Due to its unique structure (it contains three intramolecular disulfide bridges) and high affinity for some potassium channels, ShK-toxin may become a useful molecular probe for investigating potassium channels.



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Size Supplier No. VWR Catalog Number Unit Price Quantity
0.1 mg H-2358.0100 H-2358.0100BA Each (1mg) Retrieving Restricted
0.5 mg H-2358.0500 H-2358.0500BA Each (500µG) Retrieving Restricted
1 mg H-2358.1000 H-2358.1000BA Each (1mg) Retrieving Restricted
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SPECIFICATIONS

Protein/Peptide Name Stichodactyla helianthus Neurotoxin (ShK)
Synonyms ShK
CAS No. 172450-46-3
Molecular Weight 4054.83
Molecular Formula C₁₆₉H₂₇₄N₅₄O₄₈S₇
Storage Conditions -20 ± 5 °C
Salt Trifluoroacetate
Bonds Disulfide bonds between Cys3 and Cys35/Cys12 and Cys28/Cys17 and Cys32
Binding (Disulfide bonds between Cys³ and Cys³⁵/Cys¹² and Cys²⁸/Cys¹⁷ and Cys³²)
Peptide Stichodactyla helianthus Neurotoxin (ShK)
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