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Acetyl-Amyloid β/A4 Protein Precursor₇₇₀ (96-110) (cyclized)

Sequence: Ac-Asn-Trp-Cys-Lys-Arg-Gly-Arg-Lys-Gln-Cys-Lys-Thr-His-Pro-His-NH₂
CAS-No.: 289634-54-4
Mol.weight: 1918.24
SumFormula: C₈₁H₁₂₈N₃₂O₁₉S₂
Bulk item no.: H-2232
Synonym(s): Ac-APP₇₇₀ (96-110) (cyclized)#β-Amyloid / A4 Protein Precursor (APP) (96-110), analog
EINECS no.: -
MDL no.: MFCD00236785

See also the product family 'Secretase Inhibitors and Substrates'.comprising products related to β- and γ-secretase.

This cyclized peptide which is homologous to the heparin-binding domain of APP, binds strongly to heparin and inhibits binding of ¹²⁵I-labeled APP to heparin (IC₅₀= 10⁻⁷M). The peptide blocks the heparan sulfate proteoglycan-dependent stimulatory effect of APP on neurite outgrowth.

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Size Supplier No. VWR Catalog Number Unit Price Quantity
1 mg H-2232.0001 H-2232.0001BA Each (1mg) Retrieving Restricted
5 mg H-2232.0005 H-2232.0005BA Each (5mg) Retrieving Restricted
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Protein/Peptide Name Acetyl-Amyloid beta/A4 Protein Precursor₇₇₀ (96-110) (cyclized)
Synonyms Ac-APP770 (96-110) (cyclized)
CAS No. 289634-54-4
Molecular Weight 1918.24
Molecular Formula C₈₁H₁₂₈N₃₂O₁₉S₂
Storage Conditions -20 ± 5 °C
Bonds Disulfide bond
Binding (Disulfide bond)
Peptide Acetyl-Amyloid beta/A4 Protein Precursor₇₇₀ (96-110) (cyclized)
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