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Uroguanylin (human)

Supplier: BACHEM AMERICAS INC
Sequence: H-Asn-Asp-Asp-Cys-Glu-Leu-Cys-Val-Asn-Val-Ala-Cys-Thr-Gly-Cys-Leu-OH
CAS-No.: 154525-25-4
Mol.weight: 1667.88
SumFormula: C₆₄H₁₀₂N₁₈O₂₆S₄
Bulk item no.: H-2166
Synonym(s): UGN (human)
EINECS no.: -
MDL no.: MFCD18782131

Guanylin and uroguanylin are structurally related peptides which act on a transmembrane form of guanylate cyclase, termed GC-C. In mammals, they play pivotal roles in body fluid homeostasis. Less well defined additional members belonging to this family were identified in opposum and in eel.

Uroguanylin belongs to the guanylin family of cyclic guanosine monophosphate (cGMP) regulating peptides. This family of peptides shows homology to the heat stable enterotoxins produced by strains of Escherichia coli and other enteric bacteria that cause a secretory form of diarrhea. Along with the isolation of uroguanylin from urine and the subsequent demonstration of its natriuretic activity by direct effects on the kidney, uroguanylin has been suggested to play a role in the physiological maintenance of sodium balance in vivo. Uroguanylin activation of the guanylate cyclase-C/cyclic guanosine monophosphate pathway elicited analgesic effects in animal models of colonic hypersensitivity, unraveling a novel pathway to treat abdominal pain (Silos-Santiago et al. (2013)).



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Size Supplier No. VWR Catalog Number Unit Price Quantity
0.5 mg H-2166.0500 H-2166.0500BA Each (1mg) Retrieving Restricted
1 mg H-2166.1000 H-2166.1000BA Each (1mg) Retrieving Restricted
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SPECIFICATIONS

Protein/Peptide Name Uroguanylin
Synonyms UGN (human)
Species Human
CAS No. 154525-25-4
Molecular Weight 1667.88
Molecular Formula C₆₄H₁₀₂N₁₈O₂₆S₄
Storage Conditions -20 ± 5 °C
Salt Trifluoroacetate
Bonds Disulfide bonds between Cys4 and Cys12/Cys7 and Cys15
Binding (Disulfide bonds between Cys⁴ and Cys¹²/Cys⁷ and Cys¹⁵)
Peptide Uroguanylin
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