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Endotoxin Inhibitor

H-1382.0001 H-1382.0005
Sequence: H-Lys-Thr-Lys-Cys-Lys-Phe-Leu-Lys-Lys-Cys-OH

Antimicrobial peptides are produced by plants and most organisms throughout the animal kingdom including humans. Antimicrobial peptides protect against a broad range of infectious agents, as bacteria, fungi, and viruses. The amphibian skin is an especially rich source of antimicrobial peptides. See also the product families: Hepcidins LL-37 and Fragments Tuftsin and Analogs (subfamily).

The cyclic peptide KTKCKFLKKC has ben shown to form a strong complex with lipid A, the toxic component of the endotoxin lipopolysaccharide (LPS) with Ka = 0.56 · 10⁷ M⁻¹. It detoxifies LPS in vitro and prevents LPS-induced cytokine release and lethality in vivo. Furthermore, it shows neither antibiotic activity nor toxicity and might therefore be useful in the prophylaxis and treatment of LPS-mediated diseases. KTKCKFLKKC bears a structural resemblance to the peptide antibiotic and endotoxin inhibitor polymyxin B. It could be of use as an adjuvant for antibiotic therapy.



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Size Supplier No. VWR Catalog Number Unit Price Quantity
1 mg H-1382.0001 H-1382.0001BA Each (1mg) Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

5 mg H-1382.0005 H-1382.0005BA Each (5mg) Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

restricted In order to process your orders without delay, we request that you provide the required business documentation to purchase this product.

To order chemicals, medical devices, or other restricted products please provide identification that includes your business name and shipping address via email or fax 484.881.5997 referencing your VWR account number . Acceptable forms of identification are:

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Protein/Peptide Name Endotoxin Inhibitor
CAS No. 147396-10-9
Molecular Weight 1226.62
Molecular Formula C₅₅H₉₇N₁₅O₁₂S₂
Storage Temperature -20 ± 5 °C
Bonds Disulfide bond
Binding (Disulfide bond)
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