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Amyloid β-Protein (1-42)

Sequence: H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH
CAS-No.: 107761-42-2
Mol.weight: 4514.10
SumFormula: C₂₀₃H₃₁₁N₅₅O₆₀S
Bulk item no.: H-1368
Synonym(s): Aβ42#β-Amyloid (1-42)
EINECS no.: -
MDL no.: MFCD00163049

Aβ 1-42, 42-residue fragment of amyloid precursor protein, has been found to be a major constituent of the senile plaques formed in the brains of patients with Alzheimer's disease and late Down's syndrome. Aβ 1-42 readily forms neurotoxic oligomers at physiological pH. On the other hand, the peptide shows antimicrobial activity. The sequence of H-1368 corresponds to the human, bovine, canine, feline, ovine, guinea pig, and rabbit Aβ42 peptide. The peptide has been used to detect amyloid β-protein multimers in the cerebrospinal fluid of Alzheimer's disease patients through fluorescence correlation spectroscopy. For detailed descriptions of the preparation of Aβ 1-42 monomers and protofibrils please see the papers of Jan, Hartley, and Lashuel, Stine et al. (2011), and of Broersen and colleagues. The findings of Ryan et al. indicate that 10% ammonia disaggregates Aβ42 more efficiently than HFIP.

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Size Supplier No. VWR Catalog Number Unit Price Quantity
0.5 mg H-1368.0500 H-1368.0500BA Each (500µG) Retrieving Restricted
1 mg H-1368.1000 H-1368.1000BA Each (1mg) Retrieving Restricted
25 mg H-1368.0025 H-1368.0025BA Each (25mg) Retrieving Restricted
5 mg H-1368.5000 H-1368.5000BA Each (5mg) Retrieving Restricted
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Protein/Peptide Name beta-Amyloid (1-42)
CAS No. 107761-42-2
Molecular Weight 4514.10
Molecular Formula C₂₀₃H₃₁₁N₅₅O₆₀S
Storage Conditions -20 ± 5 °C
Peptide beta-Amyloid (1-42)
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