C-Type Natriuretic Peptide (32-53) (human, porcine, rat)


4019911.1000 4019911.0500
H-1296.1000BAEA 383.14 USD InStock
H-1296.1000BA H-1296.0500BA
C-Type Natriuretic Peptide (32-53) (human, porcine, rat)
Proteins and Peptides
Sequence: H-Gly-Leu-Ser-Lys-Gly-Cys-Phe-Gly-Leu-Lys-Leu-Asp-Arg-Ile-Gly-Ser-Met-Ser-Gly-Leu-Gly-Cys-OH
CAS-No.: 127869-51-6
Mol.weight: 2197.63
SumFormula: C₉₃H₁₅₇N₂₇O₂₈S₃
Bulk item no.: H-1296
Synonym(s): CNP-22 (human, porcine, rat)
EINECS no.: -
MDL no.: MFCD00080348

CNP, a member of the natriuretic peptide family, was first identified in porcine brain and later found in other mammals as well as non-mammals. Processing of the CNP precursor gives rise to CNP-22 and its N-terminally elongated form, CNP-53. The CNPs share considerable sequence homology with ANP and BNP within the disulfide loop and exert similar pharmacological actions, although with different relative potencies. CNP-22 is a potent and selective activator of the human BNP cell surface receptor, a transmembrane guanylyl cyclase. This ligand-receptor pair may be involved in the regulation of fluid homeostasis by the central nervous system.
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