Cyclo(-Ala-Glu)

Supplier: Bachem
4035536.0250 4035536.1000
G-4775.1000BAEA 2013.29 USD
G-4775.1000BA G-4775.0250BA
Cyclo(-Ala-Glu)
Proteins and Peptides
Also known as dioxopiperazines, piperazine-2,5-diones or DKPs. Diketopiperazines may occur as by-products during peptide synthesis or during the degradation of peptides. These cyclic dipeptides have been detected as taste-modulating compounds in food, they often show biological activity. DKPs are valuable chiral synthons, employed e.g. in Schöllkopf's versatile bislactim ether approach. They also have found use as catalysts for enantioselective synthesis, e.g. in the asymmetric Strecker reaction. See also the TRH metabolite cyclo(-His-Pro), G-1745, and cyclo(-Asp-Phe), G-1695, the major degradation product of aspartame.
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