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BNP-32 (human)

H-9060.0500 H-9060.1000
Sequence: H-Ser-Pro-Lys-Met-Val-Gln-Gly-Ser-Gly-Cys-Phe-Gly-Arg-Lys-Met-Asp-Arg-Ile-Ser-Ser-Ser-Ser-Gly-Leu-Gly-Cys-Lys-Val-Leu-Arg-Arg-His-OH
CAS-No.: 124584-08-3
Mol.weight: 3464.09
SumFormula: C₁₄₃H₂₄₄N₅₀O₄₂S₄
Bulk item no.: H-9060
Synonym(s): Brain Natriuretic Peptide-32 (human)#Nesiritide#BNP (1-32), human
EINECS no.: -
MDL no.: MFCD18782499

BNP, originally isolated from porcine brain, belongs to the class of natriuretic peptides, having an amino acid sequence and a pharmacological activity spectrum (including diuretic-natriuretic, hypotensive, and vasorelaxant actions) remarkably similar to that of atrial natriuretic peptide (ANP). Meanwhile, BNP precursor molecules have also been shown to exist in human and rat cardiac tissue. Comparison of the precursor sequences demonstrates structural species differences between the mammalian BNPs, a finding which contrasts with the highly conserved ANP sequences.

The secretion of the cardiac hormone BNP-32 is increased considerably in patients with congestive heart failure, successful medical treatment of this condition will result in a decrease. Yandle et al. described a method for determining hBNP in human plasma. Effects of hBNP infusion in humans have been described by Holmes et al and La Villa et al. BNP is an important biomarker in the diagnosis of heart diseases. Additionally, BNP-32 may act as a neuropeptide. BNP-32 exerts strong lipolytic effects in humans. Offered under Bolar Exemption: All APIs that are sold for development of drug products still patent protected are offered under Bolar Exemption only. The following disclaimer applies: These products are offered and sold in small quantities only and solely for uses reasonably related to privileged trials and studies for obtaining marketing authorization required by law (Bolar Exemption). Bachem cannot be made liable for any infringement of intellectual property rights. It is the sole and only responsibility of the purchaser or user of these products to comply with the relevant national rules and regulations.



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Size Supplier No. VWR Catalog Number Unit Price Quantity
0.5 mg H-9060.0500 H-9060.0500BA Each (1mg) Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

1 mg H-9060.1000 H-9060.1000BA Each (1mg) Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

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Protein/Peptide Name BNP-32
Protein Synonyms Brain Natriuretic Peptide-32 (human), Nesiritide
Species Human
CAS No. 124584-08-3
Molecular Weight 3464.09
Molecular Formula C₁₄₃H₂₄₄N₅₀O₄₂S₄
Storage Conditions -20 ± 5 °C
Salt Acetate
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