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Corticostatin I (rabbit)

Supplier: BACHEM AMERICAS INC
Sequence: H-Gly-Ile-Cys-Ala-Cys-Arg-Arg-Arg-Phe-Cys-Pro-Asn-Ser-Glu-Arg-Phe-Ser-Gly-Tyr-Cys-Arg-Val-Asn-Gly-Ala-Arg-Tyr-Val-Arg-Cys-Cys-Ser-Arg-Arg-OH
CAS-No.: 134090-73-6
Mol.weight: 3997.64
SumFormula: C₁₆₃H₂₅₉N₆₃O₄₄S₆
Bulk item no.: H-9045
Synonym(s): Defensin NP 3A (rabbit)#CS-I (rabbit)#Neutrophil Antibiotic Peptide NP-3A (rabbit)#Microbicidal Peptide NP-3A (rabbit)#Antiadrenocorticotropin Peptide I (rabbit)
EINECS no.: -
MDL no.: MFCD18782498

Antimicrobial peptides are produced by plants and most organisms throughout the animal kingdom including humans. Antimicrobial peptides protect against a broad range of infectious agents, as bacteria, fungi, and viruses. The amphibian skin is an especially rich source of antimicrobial peptides. See also the product families: Hepcidins LL-37 and Fragments Tuftsin and Analogs (subfamily).

Defensins comprise a family of small, cationic peptides prevalent in neutrophil granulocytes of humans, rabbits, guinea pigs and rats as well as in rabbit lung macrophages. These peptides show sequence homology and contain 6 conserved disulfide-linked cysteines. In vitro, all defensins display a range of prominent antimicrobial activities against bacteria, fungi, and certain enveloped viruses. In addition, human and rabbit defensins exert potent cytotoxicity in vitro against various mammalian tumor cells. The defensins act on their targets by permeabilizing the plasma membranes.

The cationic arginine- and cysteine-rich antimicrobial peptide neutrophil defensin 3a (NP-3a) has been isolated from rabbit fetal and adult lung. Rabbit NP-3a is also called corticostatin (CS-I), because it specifically inhibits corticotropin (ACTH)-stimulated corticosteroid synthesis by rat adrenal cells in vitro.



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Size Supplier No. VWR Catalog Number Unit Price Quantity
0.5 mg H-9045.0500 H-9045.0500BA Each (1mg) Retrieving Restricted
1 mg H-9045.1000 H-9045.1000BA Each (1mg) Retrieving Restricted
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SPECIFICATIONS

Protein/Peptide Name Corticostatin I
Synonyms CS-I (rabbit), Neutrophil Antibiotic Peptide NP-3A (rabbit), Microbicidal Peptide NP-3A (rabbit), Antiadrenocorticotropin Peptide I (rabbit), Defensin NP 3A (rabbit)
Species Rabbit
CAS No. 134090-73-6
Molecular Weight 3997.64
Molecular Formula C₁₆₃H₂₅₉N₆₃O₄₄S₆
Storage Conditions -20 ± 5 °C
Salt Trifluoroacetate
Bonds Disulfide bonds between Cys3 and Cys31/Cys5 and Cys20/Cys10 and Cys30
Binding (Disulfide bonds between Cys³ and Cys³¹/Cys⁵ and Cys²⁰/Cys¹⁰ and Cys³⁰)
Peptide Corticostatin I
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