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Echistatin

Supplier: BACHEM AMERICAS INC
Sequence: H-Glu-Cys-Glu-Ser-Gly-Pro-Cys-Cys-Arg-Asn-Cys-Lys-Phe-Leu-Lys-Glu-Gly-Thr-Ile-Cys-Lys-Arg-Ala-Arg-Gly-Asp-Asp-Met-Asp-Asp-Tyr-Cys-Asn-Gly-Lys-Thr-Cys-Asp-Cys-Pro-Arg-Asn-Pro-His-Lys-Gly-Pro-Ala-Thr-OH
CAS-No.: 154303-05-6
Mol.weight: 5417.12
SumFormula: C₂₁₇H₃₄₁N₇₁O₇₄S₉
Bulk item no.: H-9010
Synonym(s):
EINECS no.: -
MDL no.: MFCD00081572

Echistatin is a 49-amino acid polypeptide from the venom of the saw-scaled viper, Echis carinatus. The peptide containing an RGD motif binds to the glycoprotein IIb/IIIa receptor on the platelet and is a potent competitive inhibitor of ADPstimulated platelet aggregation mediated by fibrinogen and other factors. Furthermore, echistatin effectively inhibits osteoclastic bone resorption in vitro and in vivo.



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Size Supplier No. VWR Catalog Number Unit Price Quantity
0.1 mg H-9010.0100 H-9010.0100BA Each (100µG) Retrieving Restricted
0.5 mg H-9010.0500 H-9010.0500BA Each (1mg) Retrieving Restricted
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SPECIFICATIONS

Protein/Peptide Name Echistatin
CAS No. 154303-05-6
Molecular Weight 5417.12
Molecular Formula C₂₁₇H₃₄₁N₇₁O₇₄S₉
Storage Conditions -20 ± 5 °C
Bonds Disulfide bonds between Cys2 and Cys11/Cys7 and Cys32/Cys8 and Cys37/Cys20 and Cys39
Binding (Disulfide bonds between Cys² and Cys¹¹/Cys⁷ and Cys³²/Cys⁸ and Cys³⁷/Cys²⁰ and Cys³⁹)
Peptide Echistatin
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