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Cecropin P1

Sequence: H-Ser-Trp-Leu-Ser-Lys-Thr-Ala-Lys-Lys-Leu-Glu-Asn-Ser-Ala-Lys-Lys-Arg-Ile-Ser-Glu-Gly-Ile-Ala-Ile-Ala-Ile-Gln-Gly-Gly-Pro-Arg-OH
CAS-No.: 125667-96-1
Mol.weight: 3338.90
SumFormula: C₁₄₇H₂₅₃N₄₅O₄₃
Bulk item no.: H-5718
Synonym(s): Cecropin P1, porcine
EINECS no.: -
MDL no.: MFCD00079839

Antimicrobial peptides are produced by plants and most organisms throughout the animal kingdom including humans. Antimicrobial peptides protect against a broad range of infectious agents, as bacteria, fungi, and viruses. The amphibian skin is an especially rich source of antimicrobial peptides. See also the product families: Hepcidins LL-37 and Fragments Tuftsin and Analogs (subfamily).

The cecropins are a group of antibacterial peptides that were first isolated from the hemolymph of the giant silk moth Hyalophora cecropia.

Cecropin P1 (SWLSKTAKKLENSAKKRISEGIAIAIQGGPR), a homolog of insect cecropins isolated from pig intestine, was thought to be the first mammalian antimicrobial peptide. Later studies showed that the peptide is produced by the intestinal parasitic nematode Ascaris suum. The 31 amino acid peptide is highly potent against Gram-negative bacteria but has a reduced activity against Gram-positive bacteria. A disruptive effect on bacterial membranes has been proposed as mechanism of antimicrobial activity.



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Size Supplier No. VWR Catalog Number Unit Price Quantity
0.5 mg H-5718.0500 H-5718.0500BA Each (1mg) Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

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Protein/Peptide Name Cecropin P1
CAS No. 125667-96-1
Molecular Weight 3338.90
Molecular Formula C₁₄₇H₂₅₃N₄₅O₄₃
Storage Conditions -20 ± 5 °C
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