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Leptin (126-140) (human)

H-3492.0005 H-3492.0001
Sequence: H-Glu-Thr-Leu-Asp-Ser-Leu-Gly-Gly-Val-Leu-Glu-Ala-Ser-Gly-Tyr-OH
CAS-No.: 313220-09-6
Mol.weight: 1510.62
SumFormula: C₆₅H₁₀₃N₁₅O₂₆
Bulk item no.: H-3492
Synonym(s): Obese Gene Peptide (126-140) (human)
EINECS no.: -
MDL no.: MFCD00798729

Leptin, the product of the obese gene (ob), is a hormone secreted by adipocytes. Administration of recombinant mouse leptin in ob/ob mice - homozygous ob mutants suffering from obesity - corrected both overeating and obesity. Moreover leptin reduced the appetite and weight of mice with diet-induced obesity, and caused significant loss of body weight and fat content in lean mice. For other Leptin fragments please inquire.

ETLDSLGGVLEASGY, C-terminal fragment of human leptin, was employed for the determination of leptin in human serum by aid of a radioimmunoassay using polyclonal antibodies. The results of Hanew's study indicate that leptin (126-140) has an inhibitory role in GH secretion.



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Size Supplier No. VWR Catalog Number Unit Price Quantity
1 mg H-3492.0001 H-3492.0001BA Each (1mg) Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

5 mg H-3492.0005 H-3492.0005BA Each (5mg) Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

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Protein/Peptide Name Leptin (126-140)
Protein Synonyms Obese Gene Peptide (126-140) (human)
Species Human
CAS No. 313220-09-6
Molecular Weight 1510.62
Molecular Formula C₆₅H₁₀₃N₁₅O₂₆
Storage Conditions -20 ± 5 °C
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