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Collagen Type II Fragment

H-1604.1000 H-1604.0500
Sequence: H-Pro-Thr-Gly-Pro-Leu-Gly-Pro-Lys-Gly-Gln-Thr-Gly-Glu-Leu-Gly-Ala-Hyp-Gly-Asn-Lys-Gly-Glu-Gln-Gly-Pro-Lys-OH
CAS-No.: 144703-90-2
Mol.weight: 2488.74
SumFormula: C₁₀₆H₁₇₄N₃₂O₃₇
Bulk item no.: H-1604
Synonym(s): (Ala²⁶⁰,Hyp²⁶¹,Asn²⁶³)-Collagen Type II (245-270)
EINECS no.: -
MDL no.: MFCD00236928

These synthetic oligopeptides correspond to a region of high amino-acid sequence similarity between uteroglobin and lipocortin I. They possess a potent anti-inflammatory activity in vivo and are strong inhibitors of phospholipase A₂ (PLA₂) in vitro. The name 'antiflammins' is proposed for these peptides, which are a valuable model for the development of novel anti-inflammatory agents of therapeutic importance. See also Cortistatin-29, H-6458, and Thymic Factor, H-4865.

The collagen II fragment PTGPLGPKGQTGELGA-Hyp-GNKGEQGPK, a peptide analog of an antigenic determinant of type II collagen, prevents the onset of collagen-induced arthritis in vivo.



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Size Supplier No. VWR Catalog Number Unit Price Quantity
0.5 mg H-1604.0500 H-1604.0500BA Each (1mg) Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

1 mg H-1604.1000 H-1604.1000BA Each (1mg) Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

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Protein/Peptide Name Collagen Type II Fragment
Protein Synonyms (Ala260,Hyp261,Asn263)-Collagen Type II (245-270)
CAS No. 144703-90-2
Molecular Weight 2488.74
Molecular Formula C₁₀₆H₁₇₄N₃₂O₃₇
Storage Temperature -20 ± 5 °C
Salt Trifluoroacetate
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