4003115.0250 4003115.1000
G-1750.0250BAEA 191.4 USD InStock
G-1750.0250BA G-1750.1000BA
Proteins and Peptides
Sequence: Cyclo(-Leu-Pro)
CAS-No.: 2873-36-1
Mol.weight: 210.28
SumFormula: C₁₁H₁₈N₂O₂
Bulk item no.: G-1750
EINECS no.: 220-710-6
MDL no.: MFCD00237617

Also known as dioxopiperazines, piperazine-2,5-diones or DKPs. Diketopiperazines may occur as by-products during peptide synthesis or during the degradation of peptides. These cyclic dipeptides have been detected as taste-modulating compounds in food, they often show biological activity. DKPs are valuable chiral synthons, employed e.g. in Schöllkopf's versatile bislactim ether approach. They also have found use as catalysts for enantioselective synthesis, e.g. in the asymmetric Strecker reaction. See also the TRH metabolite cyclo(-His-Pro), G-1745, and cyclo(-Asp-Phe), G-1695, the major degradation product of aspartame.

Cyclo(Leu-Pro) showed antibacterial activity. Yan et al. observed that Cyclo(Leu-Pro) produced by Achromobacter xylosoxidans inhibited aflatoxin production by Aspergillus parasiticus. The diketopiperazine was shown to inhibit catecholamine release in vitro. It could play a role in the hypothalamic modulation of appetite suppressant circuitry.
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