Smoothened agonist dihydrochloride dihydrate

Supplier: Alfa Aesar

Synonyms: SAG hydrochloride hydrateSAG1.3 HCl

J64726-LB0 J64726-LB0 J64726-MCR J64726-MCR
AAJ64726-LB0EA 451.21 USD
AAJ64726-LB0 CAAAJ64726-LB0 AAJ64726-MCR CAAAJ64726-MCR
Smoothened agonist dihydrochloride dihydrate
Smoothened agonist dihydrochloride dihydrate

Smoothened Agonist, HCl (SAG), is a highly potent activator of Smo (smoothened)


  • Light Sensitive
  • Hygroscopic
  • Pale yellow solid


SAG is shown to act as an activator at low concentrations, but can inhibit Smo coupling at very high concentrations. The activating effects of SAG will counteract Cyclopamine or Cyclopamine-KAAD inhibition of Smo.


This chlorobenzothiophene compound is a hedgehog pathway agonist that interacts with the heptahelical domain of Smo.


Caution: Store away from strong oxidizing agents. Keep container tightly closed. Store in cool, dry conditions in well sealed containers. It is sensitive to light. It is hygroscopic in nature. Protect from humidity and water. Store under dry inert gas.

Formula: C₂₈H₂₈ClN₃OS·2HCl·2H₂O
MW: 599,00 g/mol
Storage Temperature: Refrigerator
MDL Number: MFCD14636155
CAS Number: 364590-63-6

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