Anti-DAP3K Rabbit Polyclonal AntibodySupplier: GeneTex
89361-134EA 632.15 USD89361-134
Anti-DAP3K Rabbit Polyclonal Antibody
Apoptosis is mediated by death domain containing adapter molecules and a caspase family of proteases. Certain serine/threonine protein kinases, such as ASK-1 and RIP, are mediators of apoptosis. A novel serine/threonine kinas that mediates apoptosis was recently identified and designated ZIP kinase (1). ZIP kinase contains an N-terminal kinase domain and a C-terminal leucine zipper structure and binds to ATF4 that is a member of ATF/CREB family. ZIP kinase has high sequence homology to DAP kinase (death-associated protein kinase), which is a mediator of apoptosis induced by gamma interferon. Overexpression of ZIP kinase induces apoptosis. ZIP and DAP kinases represent a novel kinase family, which mediates apoptosis through their catalytic activities. The messenger RNA was ubiquitously expressed in various tissues (1).
Western blot at 1:1000 dilution and a 52kDa band should be detected.
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