Anti-RIPK3 Mouse Monoclonal Antibody [clone: Rippy-3]

Supplier: GeneTex
89360-154EA 571.1 USD
Anti-RIPK3 Mouse Monoclonal Antibody [clone: Rippy-3]
Certain serine/threonine protein kinases, such as ASK1, RIP, DAP, and ZIP kinases, are mediators of apoptosis. Receptor interacting proteins including RIP and RIP2/RICK mediate apoptosis induced by TNFR1 and Fas, two prototype members in the death receptor family. A novel member in the RIP kinase family was recently identified and designated RIP3. RIP3 contains N-terminal kinase domain but, unlike RIP or RIP2, lacks the C-terminal death or CARD domain. RIP3 binds to RIP and TNFR1, mediates TNFR1 induced apoptosis, and attenuates RIP and TNFR1 induced NF-kB activation. Over expression of RIP3 induces apoptosis and NF-kB activation. The messenger RNA of RIP3 is expressed in a subset of adult tissues.

WB: Use at a concentration of 1 ?g/ml. Predicted molecular weight: 62 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

Type: Primary
Antigen: RIPK3
Clonality: Monoclonal
Clone: Rippy-3
Conjugation: Unconjugated
Host: Mouse
Isotype: IgG1
Reactivity: Human
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