The neurofilament class of intermediate filaments is found in high concentrations along the axons of vertebrate neurons. The family consists of three types of proteins: NF-L, NF-M, and NF-H. All three have the conserved tripartite structure of intermediate filaments, but NF-M and NF-L have long, hypervariable C-terminal tail domains that have multiple phosphorylation sites. Neurofilaments have been shown to influence axonal caliber, which is proportional to conduction velocity in mammalian neurons. Amyotrophic lateral sclerosis or Lou Gehrig’s disease has been associated with accumulation and abnormal assembly of neurofilaments in motor neurons and is thought to influence axonal degeneration.NF-L is the central member of the neurofilament family. It has been shown to form the backbone 10nm fiber on which the other neurofilamens assemble. NF-L knockout mice display no axonal NF’s, reduced axonal caliber, and delayed nerve regeneration
Type: Primary
Antigen: NEFM
Clonality: Monoclonal
Clone:
Conjugation:
Epitope:
Host: Mouse
Isotype:
Reactivity: Human
