Anti-IL1R1 Rabbit Polyclonal AntibodySupplier: GeneTex
89361-300EA 944.49 USD89361-300
Anti-IL1R1 Rabbit Polyclonal Antibody
Interleukin 1 (IL-1), which has a role as a mediator in inflammation, actually consists of 2 separate but related proteins, IL-1 alpha and IL-1 beta. Cell surface receptors for the 2 forms of IL-1 are identical. IL-1R Type I contains a single membrane-spanning segment, a large cytoplasmic region, and an extracellular, IL-1 binding portion composed of 3 immunoglobulin-like domains.
Immunoprecipitation: 1:400 - 800 dilution: Pre-clearing with a non-specific rabbit IgG is helpful to reduce background. This antbody is directed against the extracellular domain of the human IL-1R Type I, but precipitates the intact receptor expressed on human cells. ELISA: 1:1000 - 2000 dilution: In ELISA formats and other immunoreactive assays, this antibody will detect the extracellular domain of the IL-1R Type I (also called soluble IL-1R Type I or """"decoy"""" receptor) found in human body fluids, particularly in the circulation, urine and supernatants of cells and synovial fluid. RIA: 1:8000 dilution: Optimal titers for other applications should be determined by the researcher.
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