Anti-CD28 Mouse Monoclonal Antibody [clone: CD28.2]

Supplier: Genetex

GTX13463
89350-882EA 404.99 USD
89350-882
Anti-CD28 Mouse Monoclonal Antibody [clone: CD28.2]
Antibodies
Human CD28 antigen is a 44 kDa disulfide linked homodimeric T cell specific surface glycoprotein. It is a cell adhesion molecule of the immunoglobulin superfamily which is constitutively expressed on most peripheral blood T lymphocytes (approximately 95% of CD4+ cells and 50% of CD8+ cells). Mature thymocytes exhibit higher levels of CD28 than the immature cells. Activation of T cells results in enhanced CD28 expression. T cell activation requires two combined signals provided by antigen presenting cells. The first is mediated via the T cell receptor following its interaction with antigenic peptide-MHC complexes, and the second is delivered by accessory or co-stimulating molecules through their counter-receptors on T lymphocytes. CD28 bears structural homology to CTLA 4 which is expressed at very low levels on the surface of CD4+ and CD8+ peripheral blood cells only following activation. CD28 is the natural receptor for the B7/BB 1 ligand (CD80) a 55-60 kDa glycoprotein which is expressed on activated B lymphocytes, on dendritic cells and on interferon gamma treated monocytes. The binding of B7 1/BB 1 molecules to CD28 is involved in T lymphocyte activation and in the initiation and maintenance of chronic inflammation.

FACS: Use 5?l for 10^6 cells or 100 ?l of whole blood. ICC: Use at an assay dependent dilution. IHC-Fr: Use at an assay dependent dilution. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

Type: Primary
Antigen: CD28
Clonality: Monoclonal
Clone: 0
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity:
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